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Hydroxy-D-(-)-2-phenylglycine

Phenylglycine Chemical Properties

Melting point 240 °C (dec.)(lit.)
alpha -156 º (c=1, 1 N HCl)
Boiling point 295.73°C (rough estimate)
density 1.396
vapor pressure 0Pa at 25℃
refractive index -158 ° (C=1, 1mol/L HCl)
storage temp. 2-8°C
solubility 5g/l
pka 2.15±0.10(Predicted)
form Liquid
color Clear colorless to yellow
optical activity [α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility 5 g/L (20 ºC)
BRN 2210998
LogP -2.25
CAS DataBase Reference 22818-40-2(CAS DataBase Reference)
EPA Substance Registry System Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)

Safety Information

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 3
TSCA Yes
HS Code 29225000

Phenylglycine Usage And Synthesis

Chemical Properties off-white powder
Uses 4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Uses 4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Definition ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.
Flammability and Explosibility Nonflammable
Purification Methods Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

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